There is a video on youtube of someone pronouncing it and it took 45 minutes. Occupying 47 singlespaced pages of a microsoft word document in times new roman 12point font thats 189,819 letters, titin, otherwise known as connectin, is a gargantuan protein responsible for the passive elasticity of muscle. For full names of titinligands, see legend to figure 2. Titin is a protein in the human body responsible for passive muscle elasticity. To characterize these thymomaassociated muscle antigens, we cloned a number of immunopositive cdnas by immunoscreening muscle cdna libraries with sera. Q10466 is a protein that is important in the contraction of striated muscle tissues. All 189,819 letters of the chemical name of titin, the largest known protein. The longest words belong to science realclearscience. Having said that, weve got you some free printable teen titans coloring pages and even teen titan go coloring pages. Account of the authors investigations into muscle physiology pdf. The gene encoding titin is mutated in tibial muscular dystrophy. This is the complete chemical name of titinthe largest known protein. Approximately 15% of patients with myasthenia gravis mg have thymus neoplasia. The force generated by titin is usually seen as passive and independent of active force generation.
The identity of the longest word in english depends upon the definition of what constitutes a. Titin is a giant protein, greater than 1 m in length, that functions as a molecular spring which is responsible for the passive elasticity of muscle. Titin is a giant protein with multiple functions in cardiac and skeletal muscles. The giant protein titin also known as connectin is the third filament system in the sarcomere and is responsible for most passive stiffness of striated muscle in the physiological sarcomere length range. The full name of the largest known protein, titin, is 189,819 letters long, the longest iupac chemical name and often suggested as the longest english word it is not, as it is a chemical formula. The chemical name for this protein is the longest word in english. The length of the entire word is jawdroppingly aweinspiring whether it ever makes it to a. The giant protein titin journal of biological chemistry. Page 1 user manuel titan hummer xl page 2 dear user, tzora active systems ltd. Rat cardiac titin undergoes developmental isoform transition from the neonatal 3. The ttn gene provides instructions for making a very large protein called titin. How do you spell the full name of the protein titin answers. An autosomal dominant mutation dramatically altered this transformation. Until recently, a small number of titin mutations had been documented in association with human cardiomyopathies 5, 4348.
This is the complete chemical name of titinthe largest known. Look it up if youre curious because its way too long. This word is 189,819 letters long and spans 48 pages in. As a technical scientific term, the full name of titin doesnt appear in any dictionarynot just because it would take 12 full pages to wrangle the 190,000odd characters, but because of the. Oct 15, 2010 the name on the sign that marks the hill is taumatawhakatangihangakoauauotamateaturipukakapikimaungahoronukupokaiwhenuakitanatahu, which translates roughly as the summit where tamatea, the man with the big knees, the climber of mountains, the landswallower who travelled about, played his nose flute to his loved one. Elasticity and unfolding of single molecules of the giant muscle protein titin. Titan has very long chemical name so that pronounce it is hardly possible. I know the longest word in the whole english language, jimmy tells jenny by the. This letter contained 189,819 characters, it is the chemical name of titin, the largest known protein. Titin ig domains mu gao and eric lee a molecular rubber band in the extreme sport of bungee jumping, a daring athlete leaps from a great height and freefalls while a tethered cord tightens and stretches to absorb the energy from the descent. The protein limits the range of motion of the sarcomere in tension, thus contributing to the passive stiffness of muscle. This should be number 1, its so much harder to pronounce than otolaryngology or deterioration.
Additionally, comparisons are complicated because place names may be considered words, technical terms may be arbitrarily long, and. It comprises of 189819 characters that is 39 pages. Titin proteins striation a band a sarcomere look at the video clip showing muscle hierarchy. B rnprotein complex formation as determined by gelshift assays.
Dec 12, 2007 get the full longest word in a pdf file from here. A novel component in articular cartilage biomechanical sensing. Titin exhibits an interaction between its pevk segment and the actin filament resulting in viscosity, a speed dependent resistive force, which significantly influences diastolic filling in mice. It is possible the name you are searching has less than five occurrences per year. So, if dictionary editors dont dare to spare their pages on titins full name. Black boxes indicate ucuu binding motifsconsensus sites for rbm20 binding. A regular pattern of ig supermotifs defines segmental. N2ba and the rare novex12, whose function is unknown. The length of the entire word is jawdroppingly aweinspiring whether it ever makes it to a lexicon or not. This is the complete chemical name of titinthe largest. Longest word has 189,819 letters, takes three hours to. These mg with thymoma mgt patients show autoantibodies to striated muscle as well as autoantibodies to acetylcholine receptor. Other titin partners found in the pdb at least in part include obscurin, another long modular protein that forms a connection to membranes, alphaactinin, which forms the structure of the zdisk, and myomesin, which forms the structure of the mline. Role of the giant elastic protein titin in the frankstarling.
Titin expression in human articular cartilage and cultured. Its full chemical name is 189,819 letters long and, depending on how you define a word is the longest word in the english language. Nov 20, 2012 this is a video of some guy pronouncing the longest word in the world, which is the chemical name for titan aka connectin, a human protein, and the largest known protein. Titin also contains binding sites for muscle associated proteins so it serves as an adhesion template for the assembly of contractile machinery in muscle. Congenital myopathies are a clinically and genetically heterogeneous group of disorders that typically present in infancy with low muscle tone and diffuse muscle weakness. Titin word has gone out over the internet that the longest word in the english language is the chemical name for titan, one of the moons of saturn, with 189,819 characters. Comprehensive analysis of titin protein isoform and.
As the largest known protein, titin has the longest full chemical name. This protein plays an important role in muscles the body uses for movement skeletal muscles and in heart cardiac muscle. Its the chemical name for the titin protein found in humans. Mar 01, 2008 dashed red lines indicate differentially spliced segments in iband titin. Titin, or connectin, is the common name for the largest known protein. Molecular basis of titin exon exclusion by rbm20 and the. And, within species there are also differnces, such as human skeletal titin and human cardiac titin. Titin is believed to play an integral part in the contraction of striated muscle tissues. Titin connects the z line to the m line in the sarcomere. So, if dictionary editors dont dare to spare their pages on titins full name, what is the longest.
Mutations in the titin ttn gene on chromosome 2q31 most often produce autosomal dominant tibial muscular dystrophy, a distal muscular dystrophy of midadult life with prominent involvement of the tibialis anterior and toe extensor muscles. Titin is a giant protein, greater than 1 m in length, that functions as a molecular spring which is responsible for the passive elasticity of muscle in addition to keeping myosin molecules in place. Methionylthreonylthreonylglutaminylarginyltyrosylglutamylserylleucylphenylalanylalanylglutaminylleuc. Titin is a giant structural sarcomeric protein with a molecular weight of more than 3800 kd. Use these tables in addition to or in place of your backgrounds characteristics.
Longest english word titin spelled out this fact is disputed. Titin transcripts were derived from the minimal region necessary for rbm20 function labeled ag. Apr 15, 2019 as for the pevk element, only the extreme cooh terminus was included in the previous analyses. Longest word has 189,819 letters, takes three hours to pronounce. The bungee cord protects the jumper from serious injury, because its elasticity allows it.
An nterminal zdisc region and a cterminal mline region bind to the zline and mline of the sarcomere, respectively, so that a single titin molecule spans half the length of a sarcomere. Physiology quiz 2 key, 71118 preferred answers are in blue 1. The full chemical name of the human canonical form of titin, which starts methionyl. This is a list of notable long words which were formed systematically, or which are mentioned in authoritative sources, but which do not yet meet wiktionarys criteria for inclusion. Titin full name chemical name of titin full form directory. Im excited to show you all some of the cool things about this product and how it can help your conditioning. It is composed of 244 individually folded protein domains connected by unstructured peptide sequences. Red lines illustrate splicepathways for n2b and n2batitins between exons ex. Titin is a major human disease gene pubmed central pmc. Within muscle cells, titin is an essential component. Even wikipedia is unable to write the full name of chemical name of titan completely.
Jan 12, 2006 a titin construct encoding domains z1 and z2 1196 and several telethonin variants comprising the full length sequence residues 1167 or the nterminal titinbinding region 190 were. The full chemical name, containing 189,819 letters, is sometimes claimed to be the longest word in the english language. It glues together the first two iglike domains in two neighboring titin molecules. The largest human protein, it forms the third filament system in striated muscle along with actin and myosin.
The name of the protein titn is 189,819 letters long and the longest one in english. When creating a name character, you can use the following table of traits, ideals, bonds and flaws to help flesh out your character. Social security administration public data, the first name titin was not present. Definition from wiktionary, the free dictionary pages of a microsoft word document in times new roman 12point font thats 189,819 letters, titin, otherwise known as connectin, is a gargantuan protein responsible for the passive elasticity of muscle. Journal of molecular biology vol 305, issue 3, pages 377. For proper operation and to maintain the scooters operational readiness, we recommend that you read this user manual prior to using the scooter. The long word is used to name titin, which is the biggest known protein in the world.
The identity of the longest word in english depends upon the definition of what constitutes a word in the english language, as well as how length should be compared words may be derived naturally from the languages roots or formed by coinage and construction. The iupac chemical name of titin is but the name of the alleged most common chain of amino acids found in the protein. Chemical name of titin, the largest known protein, technical. One of the main job of this protein is to provide flexibility, structure and stability to sarcomeress cell structures. It comprises 244 individually folded protein domains connected by unstructured peptide. All 189,819 letters of the chemical name of titin, the. The show was so popular that the makers even brought a comedic spinoff of the series a couple of years back, which goes by the name teen titans go. Posttranslational modifications of titin from cardiac muscle. A man has been recorded spending more than three hours to pronounce what is supposedly the longest word in the english language. B domain structure of human cardiac titin and binding sites of known titinligands listed in parentheses behind the ligand name. Palindromic assembly of the giant muscle protein titin in the. To characterize these thymomaassociated muscle antigens, we cloned a number of immunopositive cdnas by immunoscreening muscle cdna libraries with sera from mgt patients. Single titin molecules span half sarcomeres from z disks to m lines in skeletal and cardiac muscle.
Once thought to be extremely rare, it is now clear that congenital myopathies are a commonly encountered clinical entity. Slightly different versions called isoforms of titin are made in different muscles. Both the shows are toprated, but we like original teen titans more. It takes brobro 3hours and 33 minutes to pronounce the whole thing, and it looks like he nods off several times in the process. A giant filamentous protein essential to the structure, development, and elasticity of muscle.
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